Welcome to New Pathways in Advanced SM.
This portal provides educational information, resources and a wide range of expert videos on Advanced Systemic Mastocytosis, (SM).
Systemic Mastocytosis is a rare mast cell neoplasm driven by the KIT D816V mutation in ~95% of cases.1–3
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Advanced SM is associated with a poor prognosis and low overall survival (<3.5 years) due to organ damage, which can include ascites, osteolytic lesions, liver dysfunction, weight loss, cytopaenias and hypersplenism.1–5
Patients may exhibit debilitating mast cell mediator symptoms, such as rash and life-threatening anaphylaxis.6
Advanced SM may be missed in patients with other myeloid neoplasms.7
Approximately two-thirds of patients with Advanced SM present with an associated haematological neoplasm, primarily of myeloid origin.8,9
The median time from symptom onset to diagnosis for patients with Advanced SM is 3 years.6
Listen to experts and download our resources to learn how to recognise symptoms in Advanced Systemic Mastocytosis, and how to perform diagnostic tests for your patients.
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